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Metandienone Wikipedia
Metandienone (also known as Dianabol)
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1. Overview
Metandienone is a synthetic anabolic–androgenic steroid (AAS) derived from testosterone. It was first introduced in the early 1960s and gained popularity among athletes and bodybuilders for its ability to increase muscle mass, strength, and performance. The compound has a relatively short half‑life, which allows it to be taken orally without significant water retention or severe estrogenic side effects.
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2. Pharmacology
Feature Details
Mechanism of action Binds to androgen receptors in muscle cells, stimulating protein synthesis and nitrogen retention; also affects other tissues such as bone, liver, and brain.
Half‑life Approximately 3–4 hours after oral ingestion (shorter than many anabolic steroids).
Bioavailability Oral administration is effective due to low first‑pass metabolism compared with some other orally active steroids.
Estrogenic potential Low; does not aromatize into estrogen, reducing the risk of gynecomastia and fluid retention.
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4. Practical considerations for use
Dosage & Cycle length
Typical starting dose: 20–30 mg per day (or divided doses to maintain steady plasma levels).
Cycle duration: 6–8 weeks is common; longer cycles may increase risk of side‑effects.
Stacking options
With testosterone (natural or exogenous): may reduce the need for high testosterone dosing, but can still provide a synergistic effect on muscle mass.
With anabolic steroids: used by bodybuilders to boost protein synthesis, though this increases hepatotoxicity risk.
Monitoring & side‑effects
Side‑effect Likely cause Management
Hepatotoxicity (elevated LFTs) Oral administration, high dose Reduce dose, consider injectable alternative, regular liver function tests
Hypercholesterolemia Estrogenic activity Monitor lipids; statins or diet changes may be necessary
Gynecomastia Elevated estrogen NSAIDs, aromatase inhibitors (e.g., anastrozole) if needed
Acne/folliculitis Hormonal shifts Topical treatments, oral antibiotics
Mood swings Hormone fluctuations Monitor, adjust dose
Patient education: Encourage adherence to dosing schedule, emphasize reporting of any adverse effects promptly, and discuss lifestyle modifications (diet, exercise) that can mitigate side effects.
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6. Key Takeaways for the Clinical Pharmacist
Drug‑drug interactions are rare but notable with medications such as rifampin, ketoconazole, and certain antiepileptics.
Patient-specific factors (renal/hepatic function, age, genetics) can influence pharmacokinetics; monitor accordingly.
Monitoring strategies: periodic liver function tests, vigilance for signs of adrenal insufficiency or hypogonadism, and adjusting doses based on therapeutic drug monitoring when feasible.
Education is essential: Inform patients about potential interactions with over‑the‑counter supplements and the importance of reporting new medications promptly.
By integrating these considerations into your practice, you can optimize therapy for individuals requiring testosterone therapy while minimizing adverse outcomes associated with drug–drug interactions.
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Prepared by:
Your Name, PharmD, BCPS
Specialist in Clinical Pharmacology
Date: 2024‑02‑01
